E-ISSN 2229-4619
  International Journal of Pharmaceutical Studies and Research
                                                                      -An Open Access Peer Reviewed e-Journal

 

 
 

BAYESIAN CONDITIONAL AUTO REGRESSIVE MODEL FOR MAPPING TUBERCULOSIS PREVALENCE IN INDIA

Authors: Venkatesan, P., Srinivasan, R., and C. Dharuman
  IJPSR/Volume III/ Issue I/ January-March, 2012/1-3
 

ABSTRACT
Bayesian Conditional Autoregressive (CAR) model is a disease mapping technique that is used to smoothening of relative risk of any disease. This model effectively borrows information from adjacent States to improve estimates for individual States. The main objective of the study is to construct the Bayesian spatial CAR model for studying tuberculosis patterns in India. National Family Health Survey data on tuberculosis were used in this study. A Markov Chain Monte Carlo (MCMC) simulation technique was used to estimate the parameter. WinBUGS software was used for disease mapping of CAR model of tuberculosis. The results of the study revealed that northeastern states having higher risk of tuberculosis than other regions. The Bayesian CAR method is proved to be a useful tool for disease modeling of tuberculosis.

A STUDY ON EFFECT OF PHYSICAL PROPERTIES ON THE QUALITY OF FORMULATIONS OF DIFFERENT PHARMACEUTICAL COMPANIES

  Authors: *K. Anand Kishore, P. Amareshwar
 

IJPSR/Volume III/ Issue I/ January-March, 2012/4-7

ABSTRACT
Tablets and capsules represent unit dosage forms in which one usual dose of the drug has been accurately placed. The present study reports the quality evaluation of tablets of two different Pharmaceutical Companies and its comparison. The tablets: Niacinamide, Ferrous Fumerate, Paracetamol in combination with Ibuprofen, Nimesulide and Ciprofloxacin were collected from two companies with their consent for quality evaluation and analysis. The tablets collected were subjected to different post-formulation tests such as Weight variation, Hardness and Disintegration rat, following standard I.P procedures. The observations were recorded and various plots have been drawn to correlate the above said parameters. From the results, it was noticed that there was no much difference in the Disintegration rate but considerable variation in the pattern of weight variation and Hardness of these companies because of change in recipients and due to the presence of other drugs. However, it could be concluded that the product formulations of company 'Y' are seen to be more reliable than company 'X'.

DEVELOPMENT & IN VITRO EVALUATION OF SUSTAINED RELEASE PELLETS OF DILTIAZEM HYDROCHLORIDE USING ETHYL CELLULOSE & HYDROXY PROPYL METHYL CELLULOSE POLYMER

  Authors: Nuzhat Mariam Elias, Shahana Sharmin, Ishtiaq Ahmed
 

IJPSR/Volume III/ Issue I/ January-March, 2012/08-17

ABSTRACT
In the present study, the effect of cellulose polymers Ethyl Cellulose & Hydroxy Propyl Methyl Cellulose, was evaluated on the release profile of drug from sustained release pellet. Diltiazem Hydrochloride, an antihypertensive, cardioprotective agent and slow channel blocker was used as a model drug to evaluate its release characteristics from different matrices. Diltiazem Hydrochloride sustained release pellets were prepared by drug loading (drug binder solution) on neutral pellets followed by spraying 6%coating solution using ethyl cellulose & hydroxy propyl methyl cellulose polymer in 95E:5H, 90E:10H, 85E:15H, 80E:20H and 75E:25H ratios. The in vitro dissolution studies of Diltiazem Hydrochloride from these sustained release pellets were carried out in pH 7.2 phosphate buffer for 1,2,3,4,5,6,7 and 8 hrs using USP-I method. Statistically significant differences were found among the drug release profile from different formulations. Polymer content with highest concentration of Ethyl cellulose on the pellets shows highest release retarding rate of the drug. The retarding capacity decreases with the decreased concentration of ethyl cellulose. The release mechanism was explored and explained with zero order, first order, Higuchi, Hixson Crowell and Korsmeyer equations. Finally the results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer concentration & the physico chemical properties of the drug