E-ISSN 2229-4619
  International Journal of Pharmaceutical Studies and Research

                                                                    -An Open Access Peer Reviewed e-Journal

 

 
 

DOSSIER SUBMISSION TO TGA FOR PRESCRIPTION ONLY MEDICINES

 

Authors: M.M.Gupta*, Varun Singh Bhati

 

IJPSR/Volume I/Issue I/July-September,2010/1-10

 

PRELIMINARY PHYTOCHEMICAL INVESTIGATION OF EXTRACT OF LEAVES OF PERGULARIA DAEMIA LINN.

 

Authors: Raman R Chandak*,Ipper G Balaji,Subhash J Devdhe.

 

IJPSR/Volume I/Issue I/July-September,2010/11-16

ABSTRACT
Pergularia daemia Linn. is an important plant described in ayurveda. This plant is used for treatment of a number of ailments like urinary disorders and cardiac problems. The leaves of Pergularia daemia Linn. of  was extracted with different organic solvents in increasing order of polarity. The results of the preliminary investigation revealed the presence of alkaloids, steroids, flavonoids, terpenoids, glycosides, & carbohydrates. The Diethyl ether and Acetone extract werestudied phytochemical and four compounds i.e.  - sitosterol, Stigmesterol were isolated by using thin layer and column chromatography. The chemical structures of the isolated compounds were established by spectroscopic techniques such as UV, IR and  NMR spectroscopy. This was again confirmed by coTLC with standard sample.

THE MECHANICAL PROPERTIES & FRACTOGRAPHY OF ALUMINIUM 6061 TIO2 COMPOSITES

 

Authors: G.S. Kataiaha*, Dr. D.P.Girish

 

IJPSR/Volume I/Issue I/July-September,2010/17-25

ABSTRACT
Study of the mechanical properties of cast aluminium alloy composites containing TiO 2 particles of size 30-50 pm and of contents ranging from 0% to 20% by weight. The liquid vortex method of production was employed and the vortex created by means of a mechanical stirrer, molten metal at 700C . The study revealed that as TiO 2 composition was increased, there were significant increase in the ultimate tensile strength (UTS), and hardness of the composite,accompanied by a reduction in its ductility. An attempt is made in the paper to provide explanations for these phenomena. The fracture behavior of the composites was altered significantly by the presence of garnet particles and the crack propagation through the matrix and the reinforcing particle clusters resulted in the final fracture.

IN VITRO ANTI INFLAMMATORY ACTIVITY OF PLECTRANTHUS AMBOINICUS (LOUR) SPRENG BY HRBC MEMBRANE STABILIZATION

 

Authors: K.Nirmala Devi*, K.Periyanayagam

 

IJPSR/Volume I/Issue I/July-September,2010/26-29

ABSTRACT
Plectranthus amboinicus (Lour) Spreng is a dicotyledonous plant belonging to the family Lamiaceae. It is a folkloric medicinal plant used to treat malarial fever, hepatopathy, renal and vesical calculi, cough, chronic asthma, epilepsy. The work on the chemical composition of the leaves revealed the presence of various flavonoids like quercetin, apigenin, luteolin, salvigenin, genkwanin. Since many flavonoids have remarkable anti inflammatory activity the present work aims at evaluating the anti inflammatory activity of P.amboinicus by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti inflammatory activity. The anti inflammatory activity of the ethanolic extract was comparable to that of the standard drug  Hydrocortisone. The percentage protection for ethanolic, aqueous extracts and hydrocortisone were 68.20, 60.60 and 77.11 respectively at 500 mcg/ml. The ethanolic extract of  P.amboinicus has significant anti inflammatory activity in comparison to aqueous extract of the same plant.

ANTIMICROBIAL ACTIVITY AND PHYTOCHEMICAL STUDY OF PHYLLANTHUS EMBLICA LINN.

 

Authors: Raghu H.S* and Ravindra. P

 

IJPSR/Volume I/Issue I/July-September,2010/30-33

ABSTRACT
In India, fruits of Phyllanthus emblica L are the most common ingredients of almost all Ayurvedic preparations like Lehya, Choorna etc. Phyllanthus emblica L fruits have been used for various disorders. This has led to the investigation of antimicrobial activity of Phyllanthus emblica L. In this study, both gram positive and gram negative organisms were used. The results show that Phyllanthus emblica L Methanolic extract exhibited a significant antimicrobial activity. The Minimum Inhibitory Concentration (MIC) exhibited by Phyllanthus emblica L methanolic extract against the tested organisms ranges between 0.261 to 0.342. The methanolic extract show more antimicrobial activity than the chloroform and Diethyl ether extracts.

PHYTOCONSTITUENTS ANALYSIS BY GC-MS, CARDIOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF BUCHANANIA AXILLARIS AGAINST DOXORUBICIN-INDUCED CARDIO TOXICITY IN ALBINO RATS

 

Authors: K.Sakthivel1*  S.Palani, R.Santhosh Kalash,    K.Devi, B.Senthil Kumar

 

IJPSR/Volume I/Issue I/July-September,2010/34-48

ABSTRACT
Buchanania axillaries(Anacardiaceae) is a traditional herbal medicine , the leaves are used to treat many diseases including cardiotoxicity.The present study was designed to scientifically evaluate the cardioprotective potential of the ethanol extract of Buchanania axillaries(BA), on Doxorubicin (DOX) induced cardiotoxicity, in albino rats. DOX is one of the most effective chemotherapeutic drugs in cancer; however, its incidence of cardiotoxicity compromises its therapeutic index. DOX-induced heart failure is thought to be caused by reduction/oxidation cycling of DOX to generate oxidative stress and cardiomyocyte cell death. A Doxorubicin dose of 20 mg/kg was selected for the present study as this dose offered significant alteration in biochemical parameters and moderate necrosis in heart. Effect of BA oral treatment for 14 days at two doses (250 mg and 500 mg/kg body weight) was evaluated against DOX-induced cardiotoxicity. Significant cardiotoxicity, depletion of endogenous antioxidants and biochemical  parameters were observed in DOX-treated animals when compared with the normal animals. The Pretreatment of DOX- induced rats with BA significantly prevented the altered biochemical variation such as marker enzymes (SGPT, SGOT, CPK, ALP and LDH), lipid profile (LDL, VLDL, TGs, HDL and Total cholesterol), and antioxidant parameters (SOD, GSH, CAT, GPx, MDA, and GR) to near normal status. Serum urea, and uric acid which increased on DOX administration, registered near normal values on pretreatment with BA. Histology of Dox-induced heart of rats pretreated with BA showed a significant recovery from cell damage. The present findings have demonstrated that the cardioprotective effects of BA in DOX-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and  inhibition of lipid peroxidation of cell membrane.

HEPATIC CELL INJURY BY ETHINYL OESTRADIOL ESTROGEN

 

Authors: Pandey Govind*, Pandey S.P.and Madhuri S.

 

IJPSR/Volume I/Issue I/July-September,2010/49-53

ABSTRACT
Estrogens are the most commonly used as oral contraceptives (OCs) to control birth and as hormonal replacement therapy (HRT) by millions of women all over the world. In men, they are mainly used for the treatment of prostate cancer. However, the excessive and prolonged use of estrogens may cause severe cytotoxicity and cancer of many organs. Most of the OCs contain a highly potent estrogen, ethinyl oestradiol (EO) as semisynthetic 17β- oestradiol. Hence, the present study was undertaken to assess the hepatic cell injury after administration of EO in female albino rats. EO was administered @ 500 g/kg, orally, weekly for 8, 12, 16, 20 and 24 weeks to the rats of groups 2 to 6, respectively. However, the rats of group 1 were given saline served as control. On the 9th week (Group 2), the hepatic tissues showed cellular swelling and focal areas of hydropic changes, including congested central veins. The hepatocytes revealed nuclear granularity of cytoplasm, indicating the degenerative changes. On the 13th week (Group 3), the hepatic tissues showed focal areas of haemorrhage, varying degree of degeneration, necrosis and perilobular fibrosis. The central veins were extremely dilated and the sinusoids were distended. On the 17th (Group 4), 21st (Group 5) and 25 th (Group 6) weeks, the hepatic cell injury was more severe, leading to severe hyperaemia, degeneration, necrosis, fibrosis and vacuolization. The extent and severity of hepatic cell injury were time dependent, which indicated that the EO @ 500 g/kg, orally, weekly for 20 to 24 weeks may cause severe hepatic cell injury.

ROUTES OF DRUG ADMINISTRATION

 

Authors: P.Verma*, A.S. Thakur,K. Deshmukh,Dr. A.K. Jha,S. Verma

 

IJPSR/Volume I/Issue I/July-September,2010/54-59

ABSTRACT
The route of administration is the way through which the dosage form is administered into the body for treatment of various diseases and disorders. Various routes of administrations play a marked role in the bioavailability of the active drug in the body. In present review these routes are included with their advantages and limitations. This is an attempt for the initials of field to familiarize with the routes of administrations with their significances.

COLON TARGETED DRUG DELIVERY USING DIFFERENT APPROACHES

 

Authors: Sharma Anuj, Jain Amit  K

 

IJPSR/Volume I/Issue I/July-September,2010/60-66

 

ABSTRACT
Although oral delivery has a become a widely accepted route of administration of therapeutic drugs, the gastrointestinal tract presents several formidable barrier to drug delivery. The delivery of drugs to the colon has a number of therapeutic implications in the field of drug delivery. In the recent times, the colon specific drug delivery system is also gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein & peptide drugs. The colon, as a site for drug delivery, is also beneficial for the treatment of disease sensitive to circadian rhythms and delivery of poorly absorbable drug. The various approaches that can be exploited to target the release of drug to the colon including prodrug formation, coating with ph sensitive polymer, coating with biodegradable polymers , embedding in biodegradable matrices, hydrogel, time release system, osmotic & bio-adhesive system. In this review article will cover both past & present approaches for achieving colon specific drug delivery.